Project description
Many Arctic and Antarctic species (fish, insects, plants) survive extreme cold by producing antifreeze proteins (AFPs) that depress the freezing point of their bodily fluids in a non-colligative manner without altering its melting point. Several mechanisms have been proposed for this thermal hysteresis, including the compelling adsorption-inhibition mechanism wherein AFPs are thought to adsorb onto the ice crystal surface at preferred growth sites thereby halting the ice crystal growth process. In pharmaceutical and food applications, this natural cryoprotective ability could be useful in the preservation of organs and food products upon freeze storage for example. Moreover, proteins with a strong binding towards interfaces may be efficient emulsifiers and useful for biomineralisation and bioremediation purposes. The project will tackle some of the remaining fundamental questions related to in vivo AFP efficacy and investigate the potential of AFPs as stabilizers of air-water and oil-water interfaces by means of an integrated physico-chemical approach. Key aspects concern (1.) a potential link between AFP solubility, surface activity, and thermal hysteresis activity, (2.) whether AFP changes its conformation upon adsorption, (3.) whether AFP adsorption is reversible or irreversible, (4.) what factors can be considered as driving forces for adsorption, (5.) whether AFPs can be used as potent emulsifiers, and (6.) whether AFPs form ordered structures at interfaces. The results will contribute to a deeper understanding
of AFP functioning on a very fundamental level. In addition, we hope that this knowledge will ultimately be translated into innovative solutions in medicine and (bio)technology where interface adsorption and regulation of ice crystal growth are important determinants of product performance and quality.Many Arctic and Antarctic species (fish, insects, plants) survive extreme cold by producing antifreeze proteins (AFPs) that depress the freezing point of their bodily fluids in a non-colligative manner without altering its melting point. Several mechanisms have been proposed for this thermal hysteresis, including the compelling adsorption-inhibition mechanism wherein AFPs are thought to adsorb onto the ice crystal surface at preferred growth sites thereby halting the ice crystal growth process. In pharmaceutical and food applications, this natural cryoprotective ability could be useful in the preservation of organs and food products upon freeze storage for example. Moreover, proteins with a strong binding towards interfaces may be efficient emulsifiers and useful for biomineralisation and bioremediation purposes. The project will tackle some of the remaining fundamental questions related to in vivo AFP efficacy and investigate the potential of AFPs as stabilizers of air-water and oil-water interfaces by means of an integrated physico-chemical approach. Key aspects concern (1.) a potential link between AFP solubility, surface activity, and thermal hysteresis activity, (2.) whether AFP changes its conformation upon adsorption, (3.) whether AFP adsorption is reversible or irreversible, (4.) what factors can be considered as driving forces for adsorption, (5.) whether AFPs can be used as potent emulsifiers, and (6.) whether AFPs form ordered structures at interfaces. The results will contribute to a deeper understanding
Requirements
We are looking for candidates with an MSc in Molecular Sciences, Life Sciences, Chemistry, Physics, or related discipline with a strong background and experience in experimental (Bio)physical Chemistry, Soft Matter Physics, or Biochemistry. The successful candidate should be enthusiastic, have a strong motivation to do research in an interdisciplinary team, and have excellent communication, analytical, and social skills.
We are looking for candidates with an MSc in Molecular Sciences, Life Sciences, Chemistry, Physics, or related discipline with a strong background and experience in experimental (Bio)physical Chemistry, Soft Matter Physics, or Biochemistry. The successful candidate should be enthusiastic, have a strong motivation to do research in an interdisciplinary team, and have excellent communication, analytical, and social skills.
We offer
A challenging job in a dynamic and ambitious, multidisciplinary research team. Gross monthly salaries € 2042,- to € 2621,- in accordance with the Collective Labor Agreement of the Dutch Universities (CAO NU). Moreover 8% bonus share (holiday supplement) is provided annually. An attractive package of fringe benefits (including excellent work facilities, child care and sport facilities). Also, we can help you find accommodation. The TU/e is an equal opportunity employer.
A challenging job in a dynamic and ambitious, multidisciplinary research team. Gross monthly salaries € 2042,- to € 2621,- in accordance with the Collective Labor Agreement of the Dutch Universities (CAO NU). Moreover 8% bonus share (holiday supplement) is provided annually. An attractive package of fringe benefits (including excellent work facilities, child care and sport facilities). Also, we can help you find accommodation. The TU/e is an equal opportunity employer.
Information
More information about the ICMS and this postdoctoral position may also be obtained from Sagitta Peters MSc, Business Manager of the ICMS (via tel. +31 (0)40 247 2482).
More information about the ICMS and this postdoctoral position may also be obtained from Sagitta Peters MSc, Business Manager of the ICMS (via tel. +31 (0)40 247 2482).
See also: www.icms.tue.nl
Application Procedure
To ensure consideration, your application should include the following documents (in PDF format):
- An application letter that outlines your qualification, interest and motivation for this position
- A CV with details on education, employment, publications, and research experience, as well as contact information for two referees.
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